The following information is about Ubiquinone.

Ubiquinone Defined

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Off-site Ubiquinone Links, User Submitted

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Mon Apr 13

• In Vitro - Complex I - NADH: Ubiquinone Oxidoreductase - Specific Binding Sites of Pesticides - University of California, Berkeley, California US - 1995: Fenazaquin [4-(4-tert-but ylphenethoxy)q uinazoline] is one of several acaricides and insecticides, including rotenone and pyridaben, that are reported to act by inhibiting NADH:ubiquinon e oxidoreductase (Complex I) (EC 1.6.99.3) in the range 1?10 nM. [3H]Fenazaquin is used here at 0.8 nMas a radioligand with electron transport particles (ETP) of bovine heart mitochondria to develop a new and rapid filtration assay with 42% specific binding (displaced by 2 ?Mrotenone). The potency of rotenoids, quinazolines, pyridaben, acetogenins, and several other disrupters of electron transport as inhibitors of NADH:ubiquinon e oxidoreductase activity generally correlates with their effectiveness in displacing [3H]fenazaquin from its binding site in ETP (r2= 0.96,n= 18). This correlation extends to the fenazaquin analog with (trifluorometh yl)-diazirinyl replacing thetert-butyl substituent assayed at 6 nM,indicating that it also acts at a high-affinity site in Complex I.

Fri Jan 23

• Causes of Parkinson's: This resource does not offer much detail but lists a few general ideas on the causes of PD on a biological level.
• Parkinson's-a mutated gene: This resource does not go into much detail about studies and explaining the meaning of its significance. However, it proposes the idea that PD may be a genetically inherited disease or caused by a mutation in a specific gene.

Mon Oct 20

• Effect of coenzyme Q10 on risk of atherosclerosi s in patients with recent myocardial infarction

Tue Oct 14

• Linus Pauling Institute at Oregon State University --- CoQ10: good academic and research round-up, including re supplementatio n & athletics: note the athletics studies suggest little aerobic benefit, but a slight improvement in workload note also that endurance athletes typically have low CoQ10 levels
• Statins Inhibit Coenzyme Q10 Synthesis.: some good tables of food-amounts, plus a great summary of whole-populati on tendencies
• Statins Inhibit Squalene Synthesis [90% of which wd otherwise be used as antioxidant]: Yet squalene is much more than a precursor to cholesterol. In fact, only 10% of synthesized squalene is used for cholesterol synthesis. The other 90% is stored or used as an antioxidant.
• The Synthesis of Cholesterol : 3rd of 3 key end-products, #1 is CoQ10 -- statins cut all 3 off from the start!!: eek! avoid statins AT ALL COSTS!

Wed Jun 11

• Ubitol by BioNutrigenics , Inc. - 30 Gelcaps

Sat Apr 26

• COENZYME Q (UBIQUINONE, UBIQUINOL AND SEMIQUINONE): boosting, synthesis

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Off-site Ubiquinone Research Links

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