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Huntingtons Disease > Mtor
The following information is about Mtor.
Mtor Defined
Stands for “target of rapamycin”; a protein that inhibits the process of autophagy.
This definition is in context to Huntingtons Disease. See more contextual defintions for Mtor.
Three Leading European Comprehensive Cancer Centres Launch An International Cooperation At Top Level
Published August 28, 2008, 4:13 am, Medical News Today
Three European cancer centres in Paris (Institut Gustave Roussy), Amsterdam (Netherlands Cancer Institute) and in Stockholm (Karolinska Institutet), have joined forces in their battle against cancer.
Pipeline for Breast Cancer Therapies is Focus of New MedPredict Report
Published August 27, 2008, 7:32 am, PR Newswire via Yahoo! Finance
MedPredict has published a new report in its oncology series entitled "Thought Leader Insight & Analysis: Breast Cancer," designed to provide critical strategic insight for pharma and biotech companies with a stake in the market for diagnostics and treatments in this disease area.
AVEO Initiates Phase 1b Combination Trial of AV-951 with FOLFOX6 in Patients with Advanced Colorectal and Other ...
Published August 25, 2008, 6:01 am, Centre Daily Times
AVEO Pharmaceuticals, Inc., a biotechnology company leveraging breakthrough discoveries in cancer biology to discover, develop and commercialize targeted oncology therapies, today announced that it has initiated another Phase 1b clinical study for its lead product candidate, the novel triple VEGF receptor inhibitor AV-951. This open-label, sequential dose escalation study will be conducted at ...
AVEO Initiates Phase 1b Combination Trial of AV-951 with FOLFOX6 in Patients with Advanced Colorectal and Other ...
Published August 25, 2008, 5:30 am, Business Wire via Yahoo! Finance
CAMBRIDGE, Mass.----AVEO Pharmaceuticals, Inc., a biotechnology company leveraging breakthrough discoveries in cancer biology to discover, develop and commercialize targeted oncology therapies, today announced that it has initiated another Phase 1b clinical study for its lead product candidate, the novel triple VEGF receptor inhibitor AV-951.
Anti-tumor Effects Are Enhanced By Inhibiting Two Pathways Rather Than One
Published August 24, 2008, 6:19 pm, Science Daily
Two independent research groups have found that simultaneous inhibition of two signaling pathways -- mTOR and MAPK signaling pathways -- results in substantially enhanced antitumor effects when compared with inhibition of either pathway alone in mouse models of prostate and breast cancer.
Inhibiting 2 Pathways Rather Than 1 Enhances Anti-Tumor Effects
Published August 24, 2008, 4:13 am, Medical News Today
Two independent research groups have found that simultaneous inhibition of two signaling pathways resulted in substantially enhanced antitumor effects in mouse models of prostate and breast cancer.
JCI table of contents: Aug. 21, 2008
Published August 21, 2008, 2:27 pm, EurekAlert!
( Journal of Clinical Investigation ) This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published Aug. 21, 2008, in the JCI: "Antitumor effects are enhanced by inhibiting 2 pathways rather than 1"; "Molecular insight into one form of the bleeding disorder von Willebrand disease"; and "Insight into the physiologic role of the blood ...
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Off-site Mtor Links, User Submitted
The following links have been collected through user bookmark submission in the Mtor category. Please note, because these resources are off-site we cannot guarantee the accuracy or quality of any information.
Thu Jun 19
- Rictor and Integrin-Linke d Kinase Interact and Regulate Akt Phosphorylatio n and Cancer Cell Survival -- McDonald et al. 68 (6): 1618 -- Cancer Research: a possible way to like the mTORC2/rictor pathway to motility - if ILK links rictor to adhesion, that could synergize with RTK activation near the surface - see figure 4
Wed Apr 16
- Novogen's NV-128 Is a Unique Inhibitor of mTOR Dephosphorylat ion Leading to Caspase Independent Death in Chemoresistant Cancer Cells: Novogen drug candidate NV-128 engages a novel mode of cell death targeting the akt-mTOR pathway in multi-drug resistant ovarian cancer cells.
Sun Apr 13
- cell-wars cancer research, latest news and articles about cancer and cell biology. Clinical trials, other news in Biology: Cell biology site with emphasis on cancer research and mechanisms of cancer resistance and understanding apoptosis pathways as well as chemotherapy mechanisms.
Thu Jan 31
Fri Jan 25
- Pediatricbrain tumors : Message: RE: [PBT] Re: Etoposide, effects? Urgent: Meryl, Loice PBT conversation about ocetretide and rampamycin and somastin inhibitors for a PBT kid who's going to do it. Meryl has a german researcher looking at ocetretide
Fri Jan 11
Mon Dec 10
Tue Oct 30
- Protective Roles for Induction of Autophagy in Multiple Proteinopathie s: Protective Roles for Induction of Autophagy in Multiple Proteinopathie s
- Rapamycin pre-treatment protects against apoptosis -- Ravikumar et al. 15 (7): 1209 -- Human Molecular Genetics
- Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease - Nature Genetics
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Off-site Mtor Research Links
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