The following information is about Mitochondria.

Mitochondria Defined

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Off-site Mitochondria Links, User Submitted

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Sat Oct 11

• Mitochondrial Mysteries - Taylor University

Wed Oct 8

• Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease : Abstract : Nature Medicine: Mitochondrial dysfunction has been described in Alzheimer' ;s disease, but how it is induced has remained unclear. The authors find that a neurotoxic amyloid protein associated with the disease binds a mitochondrial protein called cyclophilin D and causes neuron death. The authors show that Alzheimer' ;s disease model mice that lack cyclophilin D show improvements in learning and memory.
• Portal to Alzheimer's disease : Article : Nature Medicine: Genetic inactivation of the mitochondrial self-destructi on mechanism improves cognition in a mouse model of Alzheimer' ;s disease.
• Limited clinical relevance of mitochondrial DNA mutation and gene expression analyses in ovarian cancer: This tudy indicates rather limited clinical relevance of mitochondrial molecular analyses in ovarian carcinomas. These discrepancies in the clinical utility of mitochondrial molecular tests in ovarian cancer require additional large, well-designed validation studies.
• Dephosphorylat ion by calcineurin regulates translocation of Drp1 to mitochondria ? PNAS

Tue Oct 7

• The Membrane Pacemaker Hypothesis: peroxidation

Sun Oct 5

• Baldelli's issues: "Abnormalities " that cause extreme fatigue

Fri Oct 3

• Mitochondrial Disease Action Committee - MitoAction

Thu Oct 2

• Nanotechnology Now - Nanotechnology Columns

Wed Oct 1

• Mitochondria in cybrids containing mtDNA from persons with mitochondriopa thies: The cytoplasmic hybrid (cybrid) technique allows investigators to express selected mitochondrial DNA (mtDNA) sequences against fixed nuclear DNA (nDNA) backgrounds. Cybrids have been used to study the effects of known mtDNA mutations on mitochondrial biochemistry, mtDNA-nDNA inter-species compatibility, and mtDNA integrity in persons without mtDNA mutations defined previously. This review discusses events leading up to creation of the cybrid technique, as well as data obtained via application of the cybrid strategies listed above. Although interpreting cybrid data requires awareness of technique limitations, valuable insights into mtDNA genotype-funct ional phenotype relationships are suggested (15th November 2007)

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Off-site Mitochondria Research Links

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