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Huntingtons Disease > Memantine
The following information is about Memantine.
Memantine Defined
A well-tolerated drug that acts as an NMDA receptor antagonist, preventing glutamate toxicity. It may slow the progression of HD.
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Off-site Memantine Links, User Submitted
The following links have been collected through user bookmark submission in the Memantine category. Please note, because these resources are off-site we cannot guarantee the accuracy or quality of any information.
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- Effect of subchronic treatment of memantine, galan...[J Pharmacol Exp Ther. 2006] - PubMed Result: In Tg2576 mice (mutant APP expressing, APPswe).. nicotine compared to saline reduced guanidinum-sol uable amyloid-beta levels by 46-66%, left intracellular amyloid-beta levels unchanged, reduced glial fibrillary acidic protein immunoreactive astrocytes around the plaques, increased synaptophysin, and increased alpha7 nicotinic acetylcholine receptors in the cortex. Galantamine increased cortical levels of synapsophysin. Memantine reduced the total cortical levels of membrane-bound amyloid precursor protein (45-55%) in transgenic and non-transgenic mice.
Thu Oct 9
- The neuroprotectiv e agent memantine induces brain-...[Mol Cell Neurosci. 2001] - PubMed Result: memantine increased limbic BDNF mRNA levels, more pronounced and widespread at higher doses. mRNA levels were also met with higher BDNF protein levels.
- Glutamate-indu ced NF{kappa}B Activation in the Ret...[Invest Ophthalmol Vis Sci. 2008] - PubMed Result
Thu Sep 25
- Memantine for agitation/aggr ession and psychosis in moderately severe to severe Alzheimer's disease: a pooled analysis of 3 studies. [J Clin Psychiatry. 2008 Mar;69(3):341- 8.]: This post hoc analysis provides important evidence from placebo-contro lled trials that memantine may be a safe and effective treatment in Alzheimer' ;s disease patients with agitation/aggr ession or psychosis, who are otherwise prone to rapid progression. Memantine treatment provided benefits in cognitive, functional
Wed Sep 17
- Effects of NMDA receptor channel blockers, MK-801 ...[Behav Pharmacol. 2004] - PubMed Result: PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and other life science journals for biomedical articles back to the 1950s. PubMed includes links to full text articles and other related resources.
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