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Electron Transport Chain Defined

Also known as the respiratory chain. It is composed of the mitochondrial enzymes (also known as complexes I, II, III and IV) that transfer electrons from one complex to another, eventually resulting in the formation of ATP. Also referred to as the respiratory chain.

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  • In Vitro - Illustration - Mitochondrial Electron Transport Chain - Wikimedia: NADH dehydrogenase is an enzyme located in the inner mitochondrial membrane that catalyzes the transfer of electrons from NADH to coenzyme Q (CoQ). It is also called the NADH:quinone oxidoreductase . NADH dehydrogenase catalyzes electron transport from NADH to ubiquinone. NADH Dehydrogenase is the largest of respiratory complexes, the mammalian enzyme containing 45 separate polypeptide chains. The best-known inhibitor of complex I is Rotenone (used as an organic pesticide). Rotenone and rotenoids are isoflavonoids occurring in several genera of tropical leguminosae plants such as Derris (Papilionaceae ), Antonia (Loganiaceae) and Lonchocarpus (Fabaceae). There have been reports of rotenone-conta ining plants used by Indians to fish due to its ichthyotoxic effect, as early as the 17th century (Biet 1664 apud Moretti & Grenand 1982). Rotenone binds to the ubiquinone binding site of Complex I as well as piericidin A another potent inhibitor with a close structural homologue to ubiquinone.

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